Effect of chronic treatment with atenolol and prazosin in streptozotocin induced diabetic rats.
Indian J Physiol Pharmacol
;
1996 Jul; 40(3): 220-4
Article
in English
| IMSEAR
| ID: sea-106255
ABSTRACT
Diabetes-mellitus was induced in rats by single intravenous injection of (45 mg/kg) streptozotocin (STZ). STZ diabetic rats showed hypertension, decreased cardiac functions, cardiomyopathy and hypercholesterolemia observed at the end of six weeks. Chronic treatment with atenolol (10 mg/kg) for six weeks in the diabetic rats reduced the elevated blood pressure, but failed to prevent STZ induced other complications. Chronic treatment with prazosin (1 mg/kg, po) in the diabetic rats, reduced the elevated blood pressure and also partially prevented hypercholesterolemia, cardiac dysfunctions and in particular the cardiomyopathy. The results suggest that prazosin may be a better option as compared to atenolol in hypertension when it is associated with diabetes mellitus.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Atenolol
/
Female
/
Prazosin
/
Rats, Wistar
/
Streptozocin
/
Adrenergic alpha-Antagonists
/
Adrenergic beta-Antagonists
/
Diabetes Mellitus, Experimental
/
Hemodynamics
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1996
Type:
Article
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