DFP induced changes in acetylcholinesterase activity and glycogen level in certain brain regions of mice.
Indian J Physiol Pharmacol
;
1989 Oct-Dec; 33(4): 250-2
Article
in English
| IMSEAR
| ID: sea-106271
ABSTRACT
DFP in acute dose (2 mg/kg i. p.) in mice significantly inhibited acetylcholinesterase AChE) activity in five regions of brain i.e. cerebral cortex, corpus striatum, medulla, cerebellum and hypothalamus. The inhibition was accompanied by depletion of glycogen from these regions 1 hr after DFP administration. The inhibition of enzyme activity was more in corpus striatum and medulla and glycogen depletion was more in cerebral cortex in comparison to other regions of the brain. These changes may be due to stimulatory effect of DFP on these regions of brain in mice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Acetylcholinesterase
/
Brain
/
Brain Chemistry
/
Male
/
Glycogen
/
Isoflurophate
/
Animals
/
Mice
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1989
Type:
Article
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