Levels of acetyl hydrazines and rate of acetylation of isoniazid in adult tuberculosis patients.
Indian J Physiol Pharmacol
;
1985 Apr-Jun; 29(2): 83-8
Article
in English
| IMSEAR
| ID: sea-106280
ABSTRACT
Patients suffering from pulmonary tuberculosis were investigated for the levels of isoniazid (INH) and its metabolites viz. acetyl-INH, mono and diacetyl hydrazines and ammonia. It was observed that 50% of the patients are slow inactivators of INH and almost all show an increase in circulating levels of NH3 at 6 hrs. Mono and diacetyl hydrazine levels in blood and urine were detectable in all the patients up+o 24 hrs though the maximum levels were observed at different intervals after the intake of INH.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Acetylation
/
Tuberculosis, Pulmonary
/
Humans
/
Male
/
Kinetics
/
Adult
/
Ammonia
/
Hydrazines
/
Isoniazid
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1985
Type:
Article
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