Effect of dothiepin on nociceptive response in diabetic rats.
Indian J Physiol Pharmacol
;
1992 Apr; 36(2): 93-6
Article
in English
| IMSEAR
| ID: sea-106301
ABSTRACT
In alloxan-diabetic rats of 4 wk duration with blood glucose levels of about 300 mg/100 ml, the tail flick reaction time (TFRT) to thermal stimuli was significantly elevated (P less than 0.25), indicating hypoalgesia. Intraperitoneal dothiepin, injections of 25 mg & 50 mg/kg body weight per day did not significantly alter the TFRT, either in control or in diabetic rats, following either acute (one dose), or short term (once a day for five days) administration. It is concluded that at least in the dosage schedule used herein, dothiepin does not influence hypoalgesia of diabetic neuropathy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Rats
/
Rats, Inbred Strains
/
Blood Glucose
/
Pain Measurement
/
Female
/
Male
/
Random Allocation
/
Analysis of Variance
/
Diabetes Mellitus, Experimental
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1992
Type:
Article
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