Central nervous system pharmacology of propranolol.

Iyer, K S; Govindankutty, A; Radha, M

Iyer, K S; Govindankutty, A; Radha, M.

Indian J Physiol Pharmacol ; 1975 Jul-Sep; 19(3): 152-6

Article in English | IMSEAR | ID: sea-106336

ABSTRACT

ABSTRACT

In rats, propranolol potentiated alcohol and pentobarbitone hypnosis, but not barbital sleeping time, indicating enzyme inhibition as a possible mechanism of potentiation. Propranolol showed anticonvulsant effect on normal and reserpine treated rats by MES test, but showed dose related lowering of MET. Probable mechanisms are discussed.

Subject(s)

Animals; Barbital/pharmacology; Brain Chemistry/drug effects; Drug Synergism; Electroshock; Ethanol/pharmacology; Male; Pentobarbital/pharmacology; Phenoxybenzamine/pharmacology; Propranolol/pharmacology; Rats; Reserpine/antagonists & inhibitors; Seizures/prevention & control; Serotonin/analysis; Sleep/drug effects

Fulltext

XML

Search on Google

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pentobarbital / Phenoxybenzamine / Propranolol / Rats / Reserpine / Seizures / Sleep / Barbital / Brain Chemistry / Male Language: English Journal: Indian J Physiol Pharmacol Year: 1975 Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

Search on Google