Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats.
Indian J Physiol Pharmacol
;
1997 Jul; 41(3): 280-4
Article
in English
| IMSEAR
| ID: sea-106338
ABSTRACT
Theophylline is well known for its convulsant and proconvulsant action. Some experimental studies also suggest that theophylline and other methylxanthines may impair the protection of antiepileptic drugs. The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats. Pretreatment with both diazepam 4 mg/kg and sodium valproate 300 mg/kg, i.p., showed protection against PTZ kindled seizures. Theophylline, 50 mg/kg, i.p., when given before the antiepileptic drugs, failed to reverse their protection. Since theophylline has an adenosine receptor antagonist activity which may be responsible for its convulsant potential, the results indicate non-involvement of adenosinergic mechanisms in the mechanisms of actions of these antiepileptic drugs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentylenetetrazole
/
Rats
/
Seizures
/
Theophylline
/
Male
/
Valproic Acid
/
Rats, Wistar
/
Convulsants
/
Protective Agents
/
Diazepam
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1997
Type:
Article
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