Impact of scorpion Heterometrus fulvipes venom on cholinesterase rhythmicity in the tropical mouse Mus booduga.

Narayana Reddy, B S; Maniraj Bhaskar, L; Babu, K S

Narayana Reddy, B S; Maniraj Bhaskar, L; Babu, K S.

Indian J Physiol Pharmacol ; 1984 Jan-Mar; 28(1): 47-52

Article in English | IMSEAR | ID: sea-106345

ABSTRACT

ABSTRACT

Rhythmicities of acetylcholine (ACh) and acetylcholinesterase (AChE) were studied in the mouse, Mus booduga (Gray), following intramuscular injection of scorpion, Heterometrus fulvipes (C. Koch) venom. Envenomation inhibited the activity levels of ACh and AChE in all the tissues selected for experimentation. Control animals exhibited diel rhythmicity in ACh and AChE while envenomated animals showed fluctuation in the Phase (delta phi), amplitude (A), Acrophase (phi) and the extreme activity hours (X and X1).

Subject(s)

Acetylcholine/metabolism; Acetylcholinesterase/metabolism; Animals; Brain/metabolism; Cholinesterase Inhibitors; Circadian Rhythm/drug effects; Liver/metabolism; Male; Mice/metabolism; Muscles/metabolism; Scorpion Venoms/pharmacology

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Acetylcholinesterase / Scorpion Venoms / Brain / Male / Acetylcholine / Cholinesterase Inhibitors / Circadian Rhythm / Liver / Animals / Mice Language: English Journal: Indian J Physiol Pharmacol Year: 1984 Type: Article

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