Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 164-6
Article
in English
| IMSEAR
| ID: sea-106377
ABSTRACT
A number of fluoroquinolones have shown convulsive potential. The effect of Ciprofloxacin was studied in electroconvulsive seizures in mice using the tonic extensor phase as end point and seizure threshold as observational parameter. Its interaction with diclofenac and paracetamol was also studied. It was found that Ciprofloxacin produced a significant epileptogenic effect. This was potentiated by diclofenac but paracetamol had no such effect. Though the exact mechanisms involved in this effect are conjectural, role of GABA inhibitory mechanisms is a possibility.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Seizures
/
Female
/
Male
/
Ciprofloxacin
/
Anti-Inflammatory Agents, Non-Steroidal
/
Diclofenac
/
Analgesics, Non-Narcotic
/
Drug Synergism
/
Gamma-Aminobutyric Acid
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS