Antinociceptive activity of chromophoric chain substituted hemicyaninocolourants.
Indian J Physiol Pharmacol
;
1997 Apr; 41(2): 144-8
Article
in English
| IMSEAR
| ID: sea-106399
ABSTRACT
Some of the chromophoric chain substituted hemicyaninocolourants (CCHCs) were synthesized and confirmed on the basis of nitrogen analysis. These were tested for their antinociceptive activity in albino rats against tail flick technique and sodium chloride induced writhing test. Test compounds were given in graded doses (10, 20 and 50 mg/kg, intraperitoneally) and compared with morphine and aspirin as standard controls. Two compounds CCHC-1 and CCHC-2 showed antinociceptive activity in a dose-dependent manner in both the experimental models. The compound CCHC-3 did not exhibit antinociceptive activity to any significant extent.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Quinolines
/
Rats
/
Reference Standards
/
Structure-Activity Relationship
/
Tail
/
Female
/
Male
/
Sodium Chloride
/
Anti-Inflammatory Agents, Non-Steroidal
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1997
Type:
Article
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