Effect of administration of isatin on alkaline phosphatase of various organs of rat.

Singh, B; Kumar, P; Nagpaul, J P; Sharma, R; Bansal, R C

Singh, B; Kumar, P; Nagpaul, J P; Sharma, R; Bansal, R C.

Indian J Physiol Pharmacol ; 1978 Jul-Sep; 22(3): 297-300

Article in English | IMSEAR | ID: sea-106407

ABSTRACT

ABSTRACT

In vivo administration of isatin (200 mg/kg) significantly lowered the activity of rat kidney alkaline phosphatase after 5 hr but enhanced the activity of rat duodenal and jejunal enzyme after 2 and 5 hr (P less than 0.01). The increased activity of the duodenal and jejunal alkaline phosphatase might be due to the induction of the enzyme by isatin.

Subject(s)

Alkaline Phosphatase/metabolism; Animals; Brain/drug effects; Cycloheximide/pharmacology; Heart/drug effects; Indoles/pharmacology; Intestine, Small/drug effects; Isatin/pharmacology; Kidney/drug effects; Liver/drug effects; Male; Rats

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Brain / Male / Cycloheximide / Alkaline Phosphatase / Heart / Indoles / Intestine, Small / Isatin / Kidney Language: English Journal: Indian J Physiol Pharmacol Year: 1978 Type: Article

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