Evaluation of antimuscarinic activity in human volunteers: a teaching aid in clinical pharmacology.
Indian J Physiol Pharmacol
;
1995 Apr; 39(2): 163-5
Article
in English
| IMSEAR
| ID: sea-106463
ABSTRACT
The antimuscarinic activity of oxyphenonium bromide, diphenhydramine hydrochloride and astemizole were evaluated in six volunteers. The parameters used were salivary secretion, heart rate and pupillary size. The results indicated that the changes in heart rate and pupillary size and measurements were not convenient parameters for class room demonstration. However, salivary secretion and dryness of mouth were found to be reliable parameters for measurement. It was concluded that simple procedures like evaluation of antimuscarinic activity could be introduced as teaching aids in clinical pharmacology for undergraduate students.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Salivation
/
Students, Medical
/
Humans
/
Male
/
Pupil
/
Astemizole
/
Oxyphenonium
/
Muscarinic Antagonists
/
Adult
/
Diphenhydramine
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
Similar
MEDLINE
...
LILACS
LIS