Hypoglycaemic and anti-oxidant activity of Salacia oblonga Wall. extract in streptozotocin-induced diabetic rats.
Indian J Physiol Pharmacol
;
1999 Oct; 43(4): 510-4
Article
in English
| IMSEAR
| ID: sea-106499
ABSTRACT
The petroleum ether extract of the root bark of S. oblonga Wall. (Celastraceae) (SOB) was studied in streptozotocin (STZ) diabetic rats and anti-lipid peroxidative activity of the same was studied in the cardiac tissue. SOB prevented significantly the streptozotocin-induced hyperglycaemia and hypoinsulinaemia. It also produced a significant decrease in peroxidation products viz. thiobarbituric acid reactive substances (P < 0.001), conjugated dienes (P < 0.05), hydroperoxides (P < 0.001). The activity of antioxidant enzymes such as superoxide dismutase (P < 0.001), catalase (P < 0.001), GSHPxase and GSSGRase was found to be increased in the heart tissue of diabetic animals treated with SOB. These results suggest that S. oblonga root bark extract possesses anti-diabetic and anti-oxidative activity in streptozotocin-diabetic rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Medicinal
/
Rats
/
Blood Glucose
/
Female
/
Plant Extracts
/
Lipid Peroxidation
/
Rats, Sprague-Dawley
/
Diabetes Mellitus, Experimental
/
Glutathione
/
Hypoglycemic Agents
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1999
Type:
Article
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