Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma.
Indian J Physiol Pharmacol
;
1999 Apr; 43(2): 259-62
Article
in English
| IMSEAR
| ID: sea-106515
ABSTRACT
Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. Median day of death, percentage increase in host life span and changes in body weight were studied. Centchroman significantly (P < 0.05) increased the median day of death both in free and formulated systems. Also, injectable formulations exhibited a significant (P < 0.05) increase in host life span compared to free drug, hence, enhanced anti-tumor efficacy against Ehrlich ascites carcinoma.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Body Weight
/
Drug Screening Assays, Antitumor
/
Carcinoma, Ehrlich Tumor
/
Centchroman
/
Chemistry, Pharmaceutical
/
Animals
/
Mice
/
Antineoplastic Agents
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS