Lipid peroxidation and antioxidant status in patients with carcinoma of prostate.
Indian J Physiol Pharmacol
;
2006 Oct-Dec; 50(4): 350-4
Article
in English
| IMSEAR
| ID: sea-106549
ABSTRACT
Prostate cancer is the most prevalent cancer found in men above the age of fifty years and is frequently diagnosed in men between 45 and 89 years of age with a median age of 72 years. This work was undertaken to assess oxidative stress and anti oxidant status in patients with carcinoma of prostate. Glutathione (GSH), Malondialdehyde (MDA), Super Oxide Dismutase (SOD) levels in Erythrocytes and plasma Glutathione-S-Transferase (GST) levels were estimated in patients with carcinoma of prostate and compared to controls. It was observed that Erythrocyte GSH levels were significantly lower and Erythrocyte MDA & SOD levels were significantly higher in patients with carcinoma of prostate compared to controls. No significant change was observed in case of GST compared to controls. Oxidative stress may be involved in prostate cancer as evidenced by the higher MDA levels and lower GSH levels. The increased activity of antioxidant enzyme may be a compensatory regulation in response to oxidative stress.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prostatic Neoplasms
/
Superoxide Dismutase
/
Aged, 80 and over
/
Aged
/
Humans
/
Male
/
Lipid Peroxidation
/
Thiobarbituric Acid Reactive Substances
/
Erythrocytes
/
Glutathione
Limits:
Aged80
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2006
Type:
Article
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