Danazol-induced biochemical changes in the rat ovary.
Indian J Physiol Pharmacol
;
1998 Apr; 42(2): 252-8
Article
in English
| IMSEAR
| ID: sea-106569
ABSTRACT
Effect of varying doses of danazol, a synthetic steroid derivative of 17 alpha-ethinyl testosterone has been observed on the biochemistry of the rat ovary. Biochemically total proteins decreased and total lipids increased with the danazol treatment. Triglycerides, the stored form of lipids formed the major components of lipids in the treated ovaries. The amount of phospholipids, glycolipids, cholesterol and free fatty acids decreased in the ovaries with increased danazol treatment. The functional significance of these changes have been discussed with ovarian physiology especially in relation to follicular growth and atresia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ovary
/
Phospholipids
/
Rats
/
Female
/
Glycolipids
/
Rats, Wistar
/
Danazol
/
Dose-Response Relationship, Drug
/
Estrogen Antagonists
/
Fatty Acids, Nonesterified
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1998
Type:
Article
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