Modification of glybenclamide hypoglycaemia by verapamil in rabbits.
Indian J Physiol Pharmacol
;
1990 Oct; 34(4): 277-8
Article
in English
| IMSEAR
| ID: sea-106581
ABSTRACT
The study was designed to demonstrate the interaction between verapamil and glybenclamide on blood glucose in rabbits. Glybenclamide (0.05 mg/kg, po) induced hypoglycaemia was observed 1 h after treatment and persisted till 3 h. Verapamil (8 mg/kg, sc) per se produced hyperglycaemia which lasted for 2 1/2 hr. Concurrent administration of verapamil was found to impair significantly the hypoglycaemic response of glybenclamide.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Blood Glucose
/
Female
/
Male
/
Verapamil
/
Glyburide
/
Drug Interactions
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1990
Type:
Article
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