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Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine HCl-induced hepatitis rats and the protective effect of turmeric extract.
Indian J Physiol Pharmacol ; 2003 Jul; 47(3): 332-6
Article in English | IMSEAR | ID: sea-106626
ABSTRACT
This study was carried out to see the hepatobiliary clearance of 99m Tc-Mebrofenin radiopharmaceutical in D-galactosamine induced hepatic rats. Furthermore, protective effect of turmeric extract has been studied in these hepatitis rats. Hepatitis was induced with intraperitoneal injection of D-galactosamine (400 mg/kg b. wt) in these rats. 1% turmeric extract was given along with their normal diet for 15 days. Turmeric extract treatment significantly increased the hepatic uptake of radioactivity and accelerated the excretion of 99m Tc-Mebrofenin as compared to control rats. (P < 0.001). In D-galactosamine administered rats, a significant delay was observed in 99m Tc-Mebrofenin excretion as compared to controls. However, D-galactosamine administered rats, pretreated with turmeric extract or concurrently treated with turmeric extract showed a near normal pattern of 99m Tc-Mebrofenin excretion. Hence, it can be suggested that turmeric extract may improve the liver function by detoxification.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Aspartate Aminotransferases / Rats / Bile / Male / Tissue Distribution / Organotechnetium Compounds / Rats, Wistar / Plant Roots / Radiopharmaceuticals / Curcuma Language: English Journal: Indian J Physiol Pharmacol Year: 2003 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Aspartate Aminotransferases / Rats / Bile / Male / Tissue Distribution / Organotechnetium Compounds / Rats, Wistar / Plant Roots / Radiopharmaceuticals / Curcuma Language: English Journal: Indian J Physiol Pharmacol Year: 2003 Type: Article