Haematological and erythrocyte membrane changes induced by amiodarone, in rats.
Indian J Physiol Pharmacol
;
1992 Oct; 36(4): 276-8
Article
in English
| IMSEAR
| ID: sea-106641
ABSTRACT
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Phospholipids
/
Rats
/
Male
/
Hemoglobins
/
Cholesterol
/
Rats, Wistar
/
Sodium-Potassium-Exchanging ATPase
/
Erythrocyte Count
/
Erythrocyte Membrane
/
Amiodarone
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1992
Type:
Article
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