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Haematological and erythrocyte membrane changes induced by amiodarone, in rats.
Indian J Physiol Pharmacol ; 1992 Oct; 36(4): 276-8
Article in English | IMSEAR | ID: sea-106641
ABSTRACT
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phospholipids / Rats / Male / Hemoglobins / Cholesterol / Rats, Wistar / Sodium-Potassium-Exchanging ATPase / Erythrocyte Count / Erythrocyte Membrane / Amiodarone Language: English Journal: Indian J Physiol Pharmacol Year: 1992 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Phospholipids / Rats / Male / Hemoglobins / Cholesterol / Rats, Wistar / Sodium-Potassium-Exchanging ATPase / Erythrocyte Count / Erythrocyte Membrane / Amiodarone Language: English Journal: Indian J Physiol Pharmacol Year: 1992 Type: Article