Anti-inflammatory and analgesic properties of four amino-acids.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 299-305
Article
in English
| IMSEAR
| ID: sea-106657
ABSTRACT
Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only. L-isoleucine also exhibited prolonged analgesic effect while DL-isoleucine had a short lasting effect. The amino-acids produced no gastric ulceration or overt acute toxicity in doses which effectively suppress inflammation. Anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Female
/
Male
/
Carrageenan
/
Phenylbutazone
/
Anti-Inflammatory Agents, Non-Steroidal
/
Diarrhea
/
Edema
/
Amino Acids
/
Granuloma
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1984
Type:
Article
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