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Anti-inflammatory and analgesic properties of four amino-acids.
Indian J Physiol Pharmacol ; 1984 Oct-Dec; 28(4): 299-305
Article in English | IMSEAR | ID: sea-106657
ABSTRACT
Orally administered L-isoleucine, DL-isoleucine and L-leucine exhibited anti-inflammatory activity in many test models of inflammation except formaldehyde-induced inflammation. L-beta-phenylalanine inhibited carrageenan-induced oedema only. L-isoleucine also exhibited prolonged analgesic effect while DL-isoleucine had a short lasting effect. The amino-acids produced no gastric ulceration or overt acute toxicity in doses which effectively suppress inflammation. Anti-inflammatory activity seems to be related with interference with the action and/or synthesis of prostaglandins and deserves further intensive study.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Female / Male / Carrageenan / Phenylbutazone / Anti-Inflammatory Agents, Non-Steroidal / Diarrhea / Edema / Amino Acids / Granuloma Language: English Journal: Indian J Physiol Pharmacol Year: 1984 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Female / Male / Carrageenan / Phenylbutazone / Anti-Inflammatory Agents, Non-Steroidal / Diarrhea / Edema / Amino Acids / Granuloma Language: English Journal: Indian J Physiol Pharmacol Year: 1984 Type: Article