Influence of pretreatment of carbamates on dynamic pulmonary mechanics in rats exposed to sarin aerosols.
Indian J Physiol Pharmacol
;
1993 Jul; 37(3): 249-51
Article
in English
| IMSEAR
| ID: sea-106665
ABSTRACT
The effect of pretreatment of two carbamates, pyridostigmine and physostigmine on dynamic pulmonary mechanics has been studied in rats exposed to sarin aerosols. Sign-free dose of pyridostigmine (0.075 mg/kg, i.m.) or physostigmine (0.1 mg/kg, i.m.) did not significantly alter the parameters of the dynamic pulmonary mechanics 20 min after treatment. However, sarin (51.2 mg/m3, for 15 min) depressed the respiratory rate, air flow and minute volume and enhanced the transthoracic pressure and tidal volume. Pretreatment with carbamates 20 min prior to sarin exposure significantly modified or counteracted the above induced changes. It is concluded that the protective effect of carbamates is mainly due to the correction of respiratory changes caused by sarin aerosols in rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Physostigmine
/
Pyridostigmine Bromide
/
Rats
/
Sarin
/
Male
/
Carbamates
/
Respiratory Mechanics
/
Rats, Wistar
/
Aerosols
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1993
Type:
Article
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