Cardiovascular effects of a withanolide from Withania coagulans, dunal fruits.
Indian J Physiol Pharmacol
;
1983 Apr-Jun; 27(2): 129-34
Article
in English
| IMSEAR
| ID: sea-106799
ABSTRACT
A new withanolide, with a unique chemical structure similar to the aglycones of the cardiac glycosides, with mol. wt. 488 6, m. p. 260-261 degrees, isolated from the fruits of Withania coagulans, was screened for cardiovascular effects. At doses of 5 mg/kg body weight, the withanolide produced a moderate fall of blood pressure in dogs (34 +/- 2.1, mm Hg) which was blocked by atropine and not by mepyramine or propranolol. In rabbit Langendorff preparation and ECG studies, it produced myocardial depressant effects but in perfused frog heart it produced mild positive inotropic and chronotropic effects.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Anura
/
Rabbits
/
Rats
/
Regional Blood Flow
/
Respiration
/
Blood Pressure
/
Dogs
/
Electrocardiography
/
Ergosterol
/
Heart
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1983
Type:
Article
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