Comparative evaluation of dexamethasone with cyclophosphamide, chloramphenicol and cyproheptadine hydrochloride as immunosuppressive agents on skin homografts in rats and rabbits.
Indian J Physiol Pharmacol
;
1976 Jul-Sep; 20(3): 147-51
Article
in English
| IMSEAR
| ID: sea-106810
ABSTRACT
An experimental study on immunosuppressive action of cyclophosphamide, chloramphenicol and cyproheptadine hydrochloride in comparison with the control and dexamethasone was undertaken on skin homografts in rabbits and rats. The survival period of skin homografts in cyclophosphamide treated group was significantly increased (P less than 0.01) in rabbits, but there was insignificant increase in rats (P greater than 0.01). With chloramphenicol there was significant increase in survival period in both the species (P less than 0.01). Cyproheptadine did not show significant result in any of the species. The probable mechanisms of immunosuppressive action have been discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Rats
/
Transplantation, Homologous
/
Female
/
Male
/
Dexamethasone
/
Chloramphenicol
/
Skin Transplantation
/
Cyclophosphamide
/
Cyproheptadine
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1976
Type:
Article
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