Effect of Panax ginseng and diazepam on brain 5-hydroxytryptamine and its modification by diclofenac in rat.
Indian J Physiol Pharmacol
;
1999 Oct; 43(4): 505-9
Article
in English
| IMSEAR
| ID: sea-106825
ABSTRACT
Wistar male rats pretreated with anti-stress agents like, Panax ginseng (Pg) and diazepam (Diaz) were stressed by restraining for 1 h and 5-HT content of brain and hypothalamus as well as plasma corticosterone were measured spectrophotoflurometrically. Diclofenac (DICLO), a prostaglandin (PG) synthesis inhibitor was used to confirm the role of prostaglandin in restraint stress-induced elevation of central 5-HT correspondingly confirmed by elevation of plasma corticosterone and modification of the above anti-stress agents. Pg, Diaz and DICLO per se did not modify brain and hypothalamic 5-HT in control rats. But they attenuated stress-induced elevation of brain and hypothalamic 5-HT. Anti-stress action of both Pg and Diaz reflected by inhibition of stress-induced elevation of brain and hypothalamic content of 5-HT as also stress-induced concurrent elevation of plasma corticosterone were further diminished by DICLO. The mediatory action of 5-HT in anti-stress effects of Pg and Diaz may be modulated through prostaglandins.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Medicinal
/
Rats
/
Stress, Physiological
/
Anti-Anxiety Agents
/
Brain
/
Male
/
Corticosterone
/
Serotonin
/
Diclofenac
/
Rats, Wistar
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1999
Type:
Article
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