Local anaesthetic activity of some new substituted acylamides II.
Indian J Physiol Pharmacol
;
1975 Apr-Jun; 19(2): 76-80
Article
in English
| IMSEAR
| ID: sea-106844
ABSTRACT
Six new substituted acylamides, chemically related to lignocaine were studied for local anaesthetic activity and toxicity in mice, frogs and guinea pigs. Only one of these compounds, w-pyrrolidino 2, 3, 5, 6 tetramethyl acetanilide was found to possess potency comparable to lignocaine with a slightly higher therapeutic index. Study of the S.A.R. of this group indicated that by removal of two methyl groups at position 3 and 5 in the above compound, a local anaesthetic with greater potency than lignocaine may be obtained. Further exploration of the potentialities of a compound having pyrrolidine group as a part of basic side chain is indicated.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Anura
/
Piperidines
/
Propylamines
/
Pyrrolidines
/
Structure-Activity Relationship
/
Tail
/
Morpholines
/
Cornea
/
Diethylamines
/
Dimethylamines
Type of study:
Diagnostic study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1975
Type:
Article
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