Hypotensive effect of intracerebroventricular injection of norepinephrine and its modulation by alpha and beta adrenergic blockers in conscious rabbits.
Indian J Physiol Pharmacol
;
1995 Oct; 39(4): 361-8
Article
in English
| IMSEAR
| ID: sea-106894
ABSTRACT
The present study was designed to investigate the role of central adrenoceptors in the hypotensive effect of intracerebroventricular (ICV) injection of norepinephrine (NE) in conscious rabbits. Experiments were carried out on 19 adult rabbits (oryctolagus cuniculus) of either sex. A dose-dependent hypotensive response to ICV injection of NE was observed with no significant change in heart rate. The hypotensive response of NE was blocked 74.2 +/- 0.7% by yohimbine (alpha-2 adrenergic blocker), and 25.0 +/- 0.5% by metoprolol (beta-1 adrenergic blocker). NE response was not affected either by prazosin or butoxamine (alpha-1 and beta-2 adrenergic blockers respectively). The results suggest that the dose-dependent hypotensive response of ICV administered NE is mediated through alpha-2 and beta-1 central adrenoceptors.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Yohimbine
/
Blood Pressure
/
Female
/
Male
/
Butoxamine
/
Prazosin
/
Norepinephrine
/
Adrenergic alpha-Agonists
/
Adrenergic alpha-Antagonists
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
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