Effect of glutamic acid and ketamine on morphine-induced analgesic response in rats.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 33-42
Article
in English
| IMSEAR
| ID: sea-106922
ABSTRACT
Rats were treated with intraperitoneal injections of morphine (10 mg/kg) followed by glutamic acid (20 mg/kg.) and ketamine. (5 mg/kg). Pain thresholds were recorded as tail flick latencies for a period of 23 days and the mean area under curves calculated. Glutamic acid and ketamine, partially blocked the analgesic effects of morphine. Two types of effects were observed. In 4 animals, there was a partial blockade of the response, and in 2 animals there was a complete blockade followed by reversal in both the groups. It is suggested that two different mechanisms one excitatory and one inhibitory may be operating for the interaction of NMDA receptors with the opioid analgesic systems for modulating nociceptive responses.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Reaction Time
/
Pain Measurement
/
Rats, Wistar
/
Pain Threshold
/
Peripheral Nervous System
/
Glutamic Acid
/
Excitatory Amino Acid Antagonists
/
Area Under Curve
/
Drug Interactions
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS