Effect of D-400, a herbal formulation, on blood sugar of normal and alloxan-induced diabetic rats.
Indian J Physiol Pharmacol
;
1995 Apr; 39(2): 95-100
Article
in English
| IMSEAR
| ID: sea-106987
ABSTRACT
Blood sugar levels of normal rats treated with D-400 showed significant reduction (P < 0.05) as compared to control groups. The fall was seen at one month and remained so uptill 3 months. Hyperglycemic response to adrenaline was significantly lowered (P < 0.05) following D-400 treatment. D-400 potentiated the hypoglycemia following tolbutamide treatment. Blood sugar remained persistently low in tolbutamide plus D-400 treated group after 3 and 4 hours (P < 0.05). In the alloxan-induced diabetic rats, a significant lowering of blood and urinary sugar was noticed on day 20, 30 and 40 following treatment with D-400 (P < 0.05). Liver glycogen depletion was significantly inhibited in the D-400 treated group (P < 0.025). D-400 has significantly potentiated (P < 0.05) the hypoglycemic action of insulin in alloxan-induced diabetic rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Tolbutamide
/
Blood Glucose
/
Body Weight
/
Female
/
Male
/
Plant Extracts
/
Epinephrine
/
Fasting
/
Rats, Wistar
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1995
Type:
Article
Similar
MEDLINE
...
LILACS
LIS