Effect of acetazolamide on insulin sensitivity in dogs with alloxan diabetes.
Indian J Physiol Pharmacol
;
1978 Jul-Sep; 22(3): 301-4
Article
in English
| IMSEAR
| ID: sea-107012
ABSTRACT
The effect of acetazolamide on the sensitivity to exogenous insulin in the alloxanised diabetic dogs was studied. The administration of acetazolamide caused acidosis and insulin resistance. The liver insulinase activity of diabetic dogs after acetazolamide administration was also studied to evaluate the role of this enzyme for the destruction of exogenous insulin. It was observed that insulinase did not play role for the development of insulin resistance after acetazolamide administration.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Male
/
Insulin Resistance
/
Diabetes Mellitus, Experimental
/
Dogs
/
Insulysin
/
Liver
/
Animals
/
Acetazolamide
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1978
Type:
Article
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