Antagonism of apomorphine-induced cage climbing behaviour and methamphetamine stereotypy by fenfluramine in mice.
Indian J Physiol Pharmacol
;
1984 Oct-Dec; 28(4): 326-30
Article
in English
| IMSEAR
| ID: sea-107020
ABSTRACT
Pretreatment with fenfluramine (5 and 10 mg/kg, ip) in doses which induced head twitches was found to antagonize apomorphine-induced cage climbing behaviour and methamphetamine stereotypy in mice. Since fenfluramine (5 and 10 mg/kg) did not induce catalepsy it indicates that fenfluramine lacks postsynaptic striatal and mesolimbic dopamine receptor blocking activity and it is possible that the fenfluramine-induced enhancement of central 5-hydroxytryptamine neuronal transmission may be responsible for its antagonistic effect on apomorphine-induced climbing behaviour and methamphetamine stereotypy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stereotyped Behavior
/
Humans
/
Male
/
Apomorphine
/
Catalepsy
/
Fenfluramine
/
Animals
/
Methamphetamine
/
Mice
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1984
Type:
Article
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