Myocardial depressant fraction in the venom of Dendroaspis angusticeps.

Wangai, J; Ng'ang'a, J N; Mungai, S; Thairu, K; Telang, B V

Wangai, J; Ng'ang'a, J N; Mungai, S; Thairu, K; Telang, B V.

Indian J Physiol Pharmacol ; 1980 Jan-Mar; 24(1): 61-4

Article in English | IMSEAR | ID: sea-107052

ABSTRACT

ABSTRACT

Whole venom Dendroaspis angusticeps produced a negative chronotropic and ionotropic effect on the heart. Isolation of the fraction (T39) produced the same effect. Negative inotropic effect was blocked by atropine. The bradycardia may be due to a cholinergic effect and the negative ionotropic to a direct depressant effect on the myocardium.

Subject(s)

Animals; Atropine/pharmacology; Depression, Chemical; Elapid Venoms/pharmacology; Heart Rate/drug effects; Myocardial Contraction/drug effects; Rabbits; Time Factors

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rabbits / Atropine / Time Factors / Depression, Chemical / Elapid Venoms / Heart Rate / Animals / Myocardial Contraction Language: English Journal: Indian J Physiol Pharmacol Year: 1980 Type: Article

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