A perspective of smooth muscle contractility through actions of vanadium compounds.
Indian J Physiol Pharmacol
;
1999 Jul; 43(3): 277-95
Article
in English
| IMSEAR
| ID: sea-107090
ABSTRACT
Smooth muscle contraction has a characteristic step-response with successive additions of stimulating compounds, and instant reversal on withdrawing the stimulus, indicative of an equilibrium situation wherein continuous, rapid reactions are occurring. Vanadium compounds, ortho- and meta-vanadates, decavanadate and peroxovanadate, were found to contract a variety of smooth muscles. Their actions were analyzed with respect to activation of receptors, increase in the intracellular calcium concentration, and increase in calmodulin-dependent myosin light chain phosphorylation leading to contraction. A new perspective of smooth muscle contractility has emerged from the studies with vanadium compounds suggesting control mechanisms involving phosphorylation for contraction and redox for relaxation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxidation-Reduction
/
Phosphorylation
/
Vanadium Compounds
/
Sodium-Potassium-Exchanging ATPase
/
Receptors, Cell Surface
/
Ion Channels
/
Animals
/
Membrane Potentials
/
Muscle Contraction
/
Muscle Proteins
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1999
Type:
Article
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