Nitric oxide-mediated pathogenesis during nicotine and alcohol consumption.
Indian J Physiol Pharmacol
;
2008 Jan-Mar; 52(1): 11-8
Article
in English
| IMSEAR
| ID: sea-107104
ABSTRACT
Nitric oxide (NO) is formed by different cell types in response to a variety of physiological and patho-physiological stimuli. The intake of nicotine and/or alcohol has patho-physiological effects on organ function, and the progression of alcohol-/tobacco-related diseases seem to be directly influenced by NO-mediated mechanisms. Nicotine has an adverse influence on blood vessel functionality, repair and maintenance. Chronic nicotine exposure augments atherosclerosis by enhancing the production of proinflammatory cytokines by macrophages which then activate atherogenic NF-kB target genes in aortic lesions. Alcohol produces NO which speeds up the apoptosis of neutrophils. Alcohol sensitizes the liver to endotoxemic shock. Nitrosative stress and increased basal levels of NO contribute to tumour growth. The progression of disease seems to be directed via a definite NO-mediated mechanism. This review gives an insight into how intake of tobacco and alcohol may affect quality of life.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Gene Expression Regulation, Enzymologic
/
Central Nervous System Depressants
/
Oxidative Stress
/
Nicotinic Agonists
/
Nitric Oxide Synthase
/
Ethanol
/
Drug Interactions
/
Animals
/
Neoplasms
Type of study:
Etiology study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2008
Type:
Article
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