Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats.
Indian J Physiol Pharmacol
;
1979 Oct-Dec; 23(4): 291-6
Article
in English
| IMSEAR
| ID: sea-107114
ABSTRACT
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Piperazines
/
Rats
/
Stereotyped Behavior
/
Time Factors
/
Behavior
/
Humans
/
Male
/
Dose-Response Relationship, Drug
/
Drug Interactions
/
Histidine
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1979
Type:
Article
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