A functional interaction between GABA and 5-HT in inhibiting picrotoxin-induced myoclonus in rats.
Indian J Physiol Pharmacol
;
1990 Apr; 34(2): 139-42
Article
in English
| IMSEAR
| ID: sea-107151
ABSTRACT
Pretreatment with 5-hydroxytryptophan (5-HTP), a precursor of 5-HT, antagonised while pretreatment with p-chlorophenylalanine (PCPA), a 5-HT depletor, potentiated the myoclonus induced by picrotoxin, a GABA antagonist. Pretreatment with aminooxyacetic acid (AOAA), a GABA transaminase inhibitor, antagonised picrotoxin-induced myoclonus. The combined effect of the least protective doses of AOAA and 5-HTP was greater than the sum of their individual inhibitory effects on picrotoxin-induced myoclonus. Further, AOAA failed to inhibit picrotoxin-induced myoclonus in PCPA pretreated rats. These findings suggest that the central 5-HT-ergic system exerts a facilitatory influence on the GABA-ergic system and thus it is involved in the antimyoclonic action of GABA.
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Picrotoxin
/
Rats
/
Rats, Inbred Strains
/
Male
/
Serotonin
/
5-Hydroxytryptophan
/
Fenclonine
/
Gamma-Aminobutyric Acid
/
Aminooxyacetic Acid
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1990
Type:
Article
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