Effects of morphine, buprenorphine, pentazocine and nalorphine on acquisition and extinction of active avoidance responses in rats.
Indian J Physiol Pharmacol
;
1990 Jul; 34(3): 179-82
Article
in English
| IMSEAR
| ID: sea-107154
ABSTRACT
The effects of subcutaneous administration of morphine, buprenorphine, pentazocine and nalorphine were studied at two dose levels in rats (low dose x 10 and high dose x 20 of equivalent human dose) on the performance of active avoidance responses using a shuttle box. Pretraining injections of both doses of pentazocine and low dose nalorphine impaired acquisition on day 1 and day 2. Morphine and buprenorphine (at both dose levels) and high dose nalorphine did not affect the acquisition process. Post-training administration of morphine (high dose) and buprenorphine (both doses) delayed extinction of active avoidance responses. Low dose of morphine, high dose of pentazocine and both doses of nalorphine did not appreciably affect the extinction process. Mu opioid receptor agonists probably act as reinforcers to facilitate memory.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentazocine
/
Rats
/
Rats, Inbred Strains
/
Avoidance Learning
/
Buprenorphine
/
Male
/
Extinction, Psychological
/
Animals
/
Morphine
/
Nalorphine
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS