Effects of periodic weight support in a simulated weightless environment in preventing bone demineralisation.
Indian J Physiol Pharmacol
;
2003 Jan; 47(1): 81-6
Article
in English
| IMSEAR
| ID: sea-107158
ABSTRACT
Anti Orthostatic Hypokinetic posture in rats by tail suspension for 15 days (d) simulates the deconditioning effects of weightlessness on the weight bearing bones. The present study evaluates the effects of daily 4 hour (h) weight support (WS) during simulated weightlessness (S-W) in preventing these changes. Adult male albino rats were divided into three groups as (i) Control (CON, n = 12), (ii) Hind limb unweighing by tail suspension for 15 d (HU, n = 18), (iii) HU with daily 4 h WS (4 HRWS, n = 11). After 15 d tibia from all the animals were removed and subsequently dried, ashed and then calcium content of the bones were determined. HU showed reductions in the water content by 35.8%, organic matrix by 12.2% and calcium content by 33.4% of tibia. 4 h WS during S-W resulted in complete prevention of water loss and organic matrix loss and partial prevention of the loss of calcium content. Calcium content of tibia in 4 HRWS remained 15.2% less as compared to CON. These findings indicate that 4 h WS is partially successful in preventing the demineralisation effects of S-W on weight bearing bone tibia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Physical Conditioning, Animal
/
Rats
/
Tibia
/
Time Factors
/
Male
/
Weight-Bearing
/
Rats, Wistar
/
Weightlessness Simulation
/
Weightlessness Countermeasures
/
Bone Demineralization, Pathologic
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2003
Type:
Article
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