Immunopharmacological studies on picrorhiza kurroa Royle-Ex-Benth. Part V: Anti-inflammatory action: relation with cell types involved in inflammation.
Indian J Physiol Pharmacol
;
1988 Oct-Dec; 32(4): 289-92
Article
in English
| IMSEAR
| ID: sea-107233
ABSTRACT
Relative importance of various cells involved in inflammation and in anti-inflammatory action of P. kurroa extract (PK) was investigated in albino rats. Effects of chemical depletion of macrophages and polymorphs and a functional deprivement of mast cells and platelets were examined on carrageenin induced pedal inflammation as well as on anti-inflammatory effect of PK treatment in this test. Such depletions/functional deprivements altered the inflammatory response in conformity with the known role of these cells. The anti-inflammatory effect of PK treatment was counteracted at 1 hr, 3 hr and 5 hr post-insult intervals by mast cell, neutrophil and macrophage depletion respectively. Manipulation of platelets was without effect.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Male
/
Plant Extracts
/
Carrageenan
/
Cell Membrane
/
Anti-Inflammatory Agents, Non-Steroidal
/
Inflammation
/
Animals
/
Macrophages
/
Mast Cells
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1988
Type:
Article
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