Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial.
Indian J Physiol Pharmacol
;
2003 Jan; 47(1): 67-74
Article
in English
| IMSEAR
| ID: sea-107269
ABSTRACT
A randomized double-masked single drop instillation clinical trial was conducted on 60 healthy volunteers divided into 3 equal groups to compare the efficacies of centbucridine and lignocaine. One eye of each volunteer was instilled with a single drop of either 0.5% centbucridine hydrochloride, 1% centbucridine hydrochloride or 4% lignocaine hydrochloride, with the other eye as an unanaesthetized control-side effects, if any, were also recorded. The onset of anaesthesia assessed both objectively and subjectively, was quickest with lignocaine 4% (P < 0.001) followed by centbucridine 0.5% and 1%. However, the period of peak activity as well as the total duration of surface anaesthesia, and also the depth of analgesia, were significantly highest with 1% centbucridine, followed by 0.5% centbucridine and 4% lignocaine respectively. Minor side effects like burning sensations were longest with 1% centbucridine--no significant adverse effects, local or systemic, were observed. Prolonged surface anaesthetic and analgesic actions of centbucridine 1% may be advantages for longer duration ophthalmic microsurgeries.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ophthalmic Solutions
/
Tacrine
/
Female
/
Humans
/
Male
/
Double-Blind Method
/
Analysis of Variance
/
Administration, Topical
/
Adult
/
Eye
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2003
Type:
Article
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