Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.
Indian J Physiol Pharmacol
;
2005 Jan; 49(1): 111-4
Article
in English
| IMSEAR
| ID: sea-107285
ABSTRACT
Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Selenium
/
Succinate Dehydrogenase
/
Male
/
Administration, Oral
/
Rats, Wistar
/
Curcumin
/
Enzyme Inhibitors
/
L-Lactate Dehydrogenase
/
Liver
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2005
Type:
Article
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