Antagonism of bromocriptine-induced cage climbing behaviour in mice by the selective D-2 dopamine receptor antagonists, metoclopramide and molindone.
Indian J Physiol Pharmacol
;
1986 Jan-Mar; 30(1): 85-90
Article
in English
| IMSEAR
| ID: sea-107291
ABSTRACT
Bromocriptine (5-30 mg/kg, ip), 2 hr after administration, induced cage climbing behaviour in mice. Pretreatment with haloperidol, an antagonist of both D-1 and D-2 dopamine receptors, metoclopramide and molindone, the selective D-2 dopamine receptor antagonists, effectively antagonised bromocriptine-induced climbing behaviour. The results indicate that bromocriptine most probably induces climbing behaviour in mice by stimulating the postsynaptic striatal D-2 dopamine receptors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Behavior, Animal
/
Male
/
Bromocriptine
/
Receptors, Dopamine
/
Receptors, Dopamine D2
/
Dose-Response Relationship, Drug
/
Haloperidol
/
Animals
/
Metoclopramide
/
Mice
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1986
Type:
Article
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