Neuropharmacological actions of labetalol.
Indian J Physiol Pharmacol
;
1979 Jan-Mar; 23(1): 39-43
Article
in English
| IMSEAR
| ID: sea-107298
ABSTRACT
Labetalol, an alpha- and beta- adrenoceptor antagonist was investigated for its central nervous system effects in rats and mice. A marked reduction in the spontaneous motor activity with no concomittant muscle weakness was produced. The drug caused closure of eyelids in rats. Labetalol caused hypothermia and prolonged the pentobarbitone-induced hyposis. In animals trained for conditioned avoidance response the drug blocked the SCR in all the animals and CAR in a few number of animals. The drug did not protect the animals against electroshock convulsions. From the results it appears that labetalol is a central nervous system depressant.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentobarbital
/
Rats
/
Seizures
/
Avoidance Learning
/
Body Temperature
/
Female
/
Male
/
Central Nervous System
/
Conditioning, Operant
/
Depression, Chemical
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1979
Type:
Article
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