Effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline.
Indian J Physiol Pharmacol
;
1993 Oct; 37(4): 303-7
Article
in English
| IMSEAR
| ID: sea-107343
ABSTRACT
In a single dose crossover study, the effect of macrocomponents of food on the pharmacokinetics of a long acting preparation of anhydrous theophylline was investigated. Compared to fasting subjects, carbohydrate and fat rich diet caused an enhancement of absorption half life and a lower Cmax with a delayed tmax and elimination of the bronchodilator. Protein coadministration decreased AUCO-OC of the drug without significantly altering its absorption or elimination kinetics.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Theophylline
/
Female
/
Humans
/
Male
/
Dietary Carbohydrates
/
Dietary Fats
/
Dietary Proteins
/
Fasting
/
Adult
/
Delayed-Action Preparations
Type of study:
Controlled clinical trial
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1993
Type:
Article
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