Protective role of estrogen in the neurodegenerative disorders.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 43-9
Article
in English
| IMSEAR
| ID: sea-107400
ABSTRACT
Estrogen is an anabolic hormone of gonadal cells and it also modulates the growth and differentiation of non-gonadal cells like neuron/glia and protects them against the injury. The anabolic or protective actions of estrogen on the neuronal cells are mediated by the modulation of intracellular factors such as insulin like growth factor (IGF-I), tyrosine kinase A (Trk A), nerve growth factors (NGF) etc. It also modulates the action of neurotrophins which in turn regulate the synaptogenesis, synaptic plasticity and synaptic functions. By these actions estrogen prevents or slows down the neurodegenerative process.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Receptors, Estrogen
/
Neurodegenerative Diseases
/
Estrogens
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2000
Type:
Article
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