Blockade by burimamide of the effects of clonidine on cardiac contractility phosphorylase activation and cyclic adenosine monophosphate in isolated guinea pig heart.
Indian J Physiol Pharmacol
;
1980 Apr-Jun; 24(2): 77-83
Article
in English
| IMSEAR
| ID: sea-107403
ABSTRACT
Clonidine in a dose-range of 2.5 microgram to 80 microgram caused positive inotropic effect, which was accompanied by increase in the cyclic AMP levels and phosphorylase-activation of the isolated perfused guinea pig heart. Clonidine-induced biochemical and mechanical effects were blocked by burimamide, an H2-receptor antagonist Propranolol (1 x 10(-6)M), phentolamine (1 x 10(-6)M) or reserpine pretreatment, did not affect the clonidine responses on the perfused guinea pig heart. Clonidine reduced the 4-methyl-histamine (H2-agonist) responses of guinea pig heart. Our data suggest that the cardiac effects of clonidine may be due to stimulation of H2-type of receptors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phosphorylase a
/
Stimulation, Chemical
/
Thiourea
/
Burimamide
/
Female
/
Male
/
Receptors, Histamine H2
/
Clonidine
/
Cyclic AMP
/
Dose-Response Relationship, Drug
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1980
Type:
Article
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