The effect of delta sleep-inducing peptide on the EEG and power spectra in rat.
Indian J Physiol Pharmacol
;
2000 Oct; 44(4): 428-34
Article
in English
| IMSEAR
| ID: sea-107426
ABSTRACT
The effects of delta sleep-inducing peptide (DSIP) on the EEG and power spectra of adult male Wistar rats (b.w. 180-220 g) were studied by power spectra analyses of EEG wave forms recorded continuously for 12 h after DSIP administration. The animals were given DSIP i.p. (1 mg/kg). Saline-injected rats served as the corresponding control. Recorded bursts of high amplitude EEG in the 1-9 Hz range (delta and theta) were found to be more frequent in DSIP-treated animals, while power spectra and (delta) wave activity were enhanced in comparison with the control and a statistically significant increase was registered in all experimental points after DSIP (2 h P < 0.05; 4 h P < 0.05; 5 h P < 0.05; 6 h P < 0.05; 7 h P < 0.01; 11 h P < 0.05). In addition, DSIP significantly elevated both the EEG output in the (delta) range and sleep activity. These results suggest that DSIP should be considered as a potential agent for the treatment of sleep disturbances in human medicine.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Delta Sleep-Inducing Peptide
/
Male
/
Rats, Wistar
/
Delta Rhythm
/
Electroencephalography
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2000
Type:
Article
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