Impairment of blood-brain barrier (BBB) in rat by immobilization stress: role of serotonin (5-HT).
Indian J Physiol Pharmacol
;
1981 Apr-Jun; 25(2): 111-22
Article
in English
| IMSEAR
| ID: sea-107432
ABSTRACT
Influence of immobilization stress on blood-brain barrier (BBB) was studied in rats using Evans blue as barrier tracer. 7-9 hr of of immobilization had increased the permeability of BBB mainly in younger rats. This increased permeability was significantly reduced with p-CPA, indomethacin or vinblastine pretreatment. Theophylline treatment caused early extravasation of Evans blue dye. The increased level of serotonin in immobilization and infusion of 5-HT in model experiments suggest a causative role of serotonin in the increased permeability of BBB induced by immobilization stress.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Stress, Physiological
/
Brain
/
Female
/
Male
/
Blood-Brain Barrier
/
Serotonin
/
Immobilization
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1981
Type:
Article
Similar
MEDLINE
...
LILACS
LIS