Effect of HD-03--a herbal formulation in galactosamine-induced hepatopathy in rats.

Mitra, S K; Seshadri, S J; Venkataranganna, M V; Gopumadhavan, S; Udupa, U V; Sarma, D N

Mitra, S K; Seshadri, S J; Venkataranganna, M V; Gopumadhavan, S; Udupa, U V; Sarma, D N.

Indian J Physiol Pharmacol ; 2000 Jan; 44(1): 82-6

Article in English | IMSEAR | ID: sea-107451

ABSTRACT

ABSTRACT

The effect of HD-03 a herbal preparation was studied on galactosamine (400 mg/kg b.wt., i.p.) induced hepatotoxicity in rats. Animals were pre-treated for 14 days with HD-03 and compared against untreated group for SGPT, SGOT, serum bilirubin and liver glycogen. Histopathology of liver lobes was considered to evaluate the extent of hepatic injury induced by galactosamine. These were reversed by HD-03 pre-treatment. HD-03 provided convincing evidence of hepatoprotection against galactosamine induced hapatotoxicity.

Subject(s)

Magnoliopsida/therapeutic use; Animals; Bile Ducts/pathology; Female; Galactosamine; Chemical and Drug Induced Liver Injury/metabolism; Liver/pathology; Liver Function Tests; Male; Necrosis; Phytotherapy; Plant Extracts/therapeutic use; Rats; Rats, Wistar

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Bile Ducts / Female / Male / Plant Extracts / Rats, Wistar / Magnoliopsida / Chemical and Drug Induced Liver Injury / Galactosamine / Liver Language: English Journal: Indian J Physiol Pharmacol Year: 2000 Type: Article

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