Toxicological study of Semecarpus anacardium nut extract.
Indian J Physiol Pharmacol
;
1979 Apr-Jun; 23(2): 115-20
Article
in English
| IMSEAR
| ID: sea-107457
ABSTRACT
Toxicological study was carried out in rats with chloroform-soluble fraction of the nuts of Semecarpus anacardium to determine its safe non-toxic dose. The fraction produced toxicity at all levels tested (50-400 mg/kg) but the extent of toxicity was found dose-dependent. At lower doses this fraction induced partial growth inhibition over 36 days and higher doses proved fatal within 6 days. It was observed that 230 mg/kg caused 50% mortality in rats and this value is 1380 mg/m2 when expressed for body surface area. This work will be of some use in the cancer chemotherapy study of the fraction.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Medicinal
/
Rats
/
Time Factors
/
Behavior, Animal
/
Body Weight
/
Male
/
Plant Extracts
/
Lethal Dose 50
/
Animals
/
Nuts
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1979
Type:
Article
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