Effect of mepyramine on the histaminase release induced by heparin injection and anaphylaxis in guinea pigs.
Indian J Physiol Pharmacol
;
1980 Oct-Dec; 24(4): 351-6
Article
in English
| IMSEAR
| ID: sea-107518
ABSTRACT
Injection of heparin as well as antigenic challenge in sensitized guinea pigs are known to produce a release of histaminase into the plasma. In the present study, tissue histaminase estimation was done by Spencer's method (17) and plasma estimation by Kapellar Adler's (7) method. Mepyramine pretreatment considerably decreased the histaminase release by both heparin and anaphylaxis. Mepyramine did not antagonise the anticoagulant action of heparin in vitro.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrilamine
/
Female
/
Male
/
Heparin
/
Amine Oxidase (Copper-Containing)
/
Guinea Pigs
/
Aminopyridines
/
Anaphylaxis
/
Liver
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1980
Type:
Article
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