Regional metabolism of 5-hydroxytryptamine in brain under acute and chronic heat stress.
Indian J Physiol Pharmacol
;
1993 Jan; 37(1): 8-12
Article
in English
| IMSEAR
| ID: sea-107604
ABSTRACT
The metabolic alteration of 5-HT in four different regions of rat brain and plasma was studied under acute and chronic heat stress. A generalised elevation of 5-HT in all the brain regions along with high plasma level was observed in animals subjected to 4 hour heat stress at 38 degrees C. Such elevation of brain 5-HT may be due to entry of plasma 5-HT into the brain owing to breakdown of blood-brain barrier (BBB). In heat adapted rats, where BBB remained unaffected, no increase in brain 5-HT was observed, rather a significantly low level was maintained both in plasma and brain tissue.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Stress, Physiological
/
Brain
/
Female
/
Male
/
Adaptation, Physiological
/
Blood-Brain Barrier
/
Serotonin
/
Acute Disease
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1993
Type:
Article
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